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  • Title: Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum.
    Author: Noguez JH, Diyabalanage TK, Miyata Y, Xie XS, Valeriote FA, Amsler CD, McClintock JB, Baker BJ.
    Journal: Bioorg Med Chem; 2011 Nov 15; 19(22):6608-14. PubMed ID: 21737286.
    Abstract:
    Palmerolides D-G are new bioactive macrolides isolated from the Antarctic tunicate Synoicum adareanum and are related to the melanoma-selective cytotoxin palmerolide A. Most of these palmerolides are potent V-ATPase inhibitors and have sub-micromolar activity against melanoma. Though palmerolide A remains the most potent of this series of natural products against mammalian V-ATPase, recent data suggests that palmerolide D is the most potent against melanoma. A comparison of the bioactivity data obtained for these natural product palmerolides has provided insight into the substructures necessary to retain V-ATPase inhibition and cytotoxic activity.
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