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  • Title: Therapeutic drug monitoring of voriconazole after intravenous administration in infants and children with primary immunodeficiency.
    Author: Gerin M, Mahlaoui N, Elie C, Lanternier F, Bougnoux ME, Blanche S, Lortholary O, Jullien V.
    Journal: Ther Drug Monit; 2011 Aug; 33(4):464-6. PubMed ID: 21743382.
    Abstract:
    OBJECTIVE: A voriconazole trough concentration (Ctrough) <1 mg/L is associated with a higher risk of treatment failure. The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole. METHODS: Voriconazole trough concentrations obtained during routine therapeutic drug monitoring over a 5-year period were collected retrospectively from infants and children receiving intravenous voriconazole for presumed or proven invasive fungal infections. RESULTS: Sixty-two trough concentrations were obtained from 6 infants and 10 children. The risk of a Ctrough <1 mg/L was 77% and 47%, respectively. Daily doses between 20 and 32 mg/kg were necessary in some patients to achieve a Ctrough >1 mg/L, compared with the currently recommended 14-mg/kg regimen. CONCLUSIONS: Routine therapeutic drug monitoring is potentially helpful in infants and children receiving voriconazole, even intravenously.
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