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  • Title: Noncirrhotic hyperammonaemic encephalopathy.
    Author: Laish I, Ben Ari Z.
    Journal: Liver Int; 2011 Oct; 31(9):1259-70. PubMed ID: 21745294.
    Abstract:
    Adult hyperammonaemia is associated with severe liver disease in 90% of cases. In the remainder, noncirrhotic causes should be considered. Measurements of serum ammonia level must be part of the basic work-up in all patients presenting with encephalopathy of unknown origin, even when liver function is normal. Clinician awareness of noncirrhotic hyperammonaemic encephalopathy can contribute to early diagnosis and the initiation of sometimes life-saving treatment. This review focuses on the physiology, aetiology and underlying mechanisms of noncirrhotic hyperammonaemic encephalopathy and discusses the available treatment modalities.
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