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  • Title: Contributions of two types of calcium channels to synaptic transmission and plasticity.
    Author: Edmonds B, Klein M, Dale N, Kandel ER.
    Journal: Science; 1990 Nov 23; 250(4984):1142-7. PubMed ID: 2174573.
    Abstract:
    In Aplysia sensory and motor neurons in culture, the contributions of the major classes of calcium current can be selectively examined while transmitter release and its modulation are examined. A slowly inactivating, dihydropyridine-sensitive calcium current does not contribute either to normal synaptic transmission or to any of three different forms of plasticity: presynaptic inhibition, homosynaptic depression, and presynaptic facilitation. This current does contribute, however, to a fourth form of plasticity--modulation of transmitter release by tonic depolarization of the sensory neuron. By contrast, a second calcium current, which is rapidly inactivating and dihydropyridine-insensitive, contributes to release elicited by the transient depolarization of an action potential and to the other three forms of plasticity.
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