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  • Title: Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule.
    Author: Lin WY, Lu Y, Su JH, Wen ZH, Dai CF, Kuo YH, Sheu JH.
    Journal: Mar Drugs; 2011; 9(6):994-1006. PubMed ID: 21747744.
    Abstract:
    Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.
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