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  • Title: [The effect of morphine, galanthamine and piracetam on conditioned reflex and brain ATPase activities in the postoperative period].
    Author: Zlenko ET, Khomiak NV.
    Journal: Farmakol Toksikol; 1990; 53(5):20-2. PubMed ID: 2174796.
    Abstract:
    In the experiments on 300 rats it was established that morphine (5 mg/kg) and galantamine (0.5 mg/kg) exert the normalizing effect on the higher nervous activity in rats during the postoperative period. It is correlated with an increase of Pa,K-ATP activity of the cerebral hemispheric cortex. Administration of piracetam (200 mg/kg) following the previous laparotomy aggravates disturbances of the higher nervous activity occurring after the operative injury and decreases Mg-ATP activity of the cortex of the cerebral hemispheres and hippocampus.
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