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  • Title: [Cerebrovascular disorders associated with livedo (Sneddon's syndrome): its relation to lupus anticoagulant].
    Author: Kalashnikova LA, Prudnikova LZ, Nasonov EP.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1990; 90(7):104-7. PubMed ID: 2175072.
    Abstract:
    The clinical manifestations of Sneddon's syndrome (cerebrovascular disorder, livedo reticularis, peripheral venous thrombosis++, cardiac pathology, obstetric pathology--fetal loss and intrauterine fetal death) are characteristic of the antiphospholipid syndrome. A lupus anticoagulant (LA), one of the types of antiphospholipid antibodies, was detected in the blood plasma of 18 out of 30 patients with Sneddon's syndrome. The negative results of LA-examination in 12 patients don't exclude the presence of other antiphospholipid antibodies. So 16 of 30 patients had anticardiolipin antibodies, among them being 6 LA-negative patients. The authors discuss the significance of antiphospholipid antibodies in the genesis of vascular abnormalities in patients with Sneddon's syndrome.
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