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  • Title: The effect of long-term imipramine treatment on carbon dioxide-induced anxiety in panic disorder patients.
    Author: Woods SW, Charney DS, Delgado PL, Heninger GR.
    Journal: J Clin Psychiatry; 1990 Dec; 51(12):505-7. PubMed ID: 2175307.
    Abstract:
    The authors examined whether long-term treatment with imipramine would decrease CO2-induced anxiety in 10 patients with panic disorder. The patients underwent CO2 testing after single-blind placebo testing and again after imipramine treatment. Scores on self-rated visual analog mood scales and panic attack symptom scales showed that the anxiogenic effects of CO2 were significantly reduced during long-term imipramine treatment. These results suggest that the mechanisms underlying CO2-induced anxiety may be similar to those involved in the pathophysiology of panic disorder.
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