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  • Title: Synthesis of aryl aldimines and their activity against fungi of clinical interest.
    Author: da Silva CM, da Silva DL, Martins CV, de Resende MA, Dias ES, Magalhães TF, Rodrigues LP, Sabino AA, Alves RB, de Fátima Â.
    Journal: Chem Biol Drug Des; 2011 Nov; 78(5):810-5. PubMed ID: 21756287.
    Abstract:
    Aldimines are aldehyde-derived compounds that contain a C=N group. Besides its broad industrial applications, this class of non-naturally occurring compounds are found to possess antibacterial, antifungal, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Based on this, six aryl aldimines were synthesized from the condensation of aromatic amines with benzaldehydes. The antifungal activities of synthesized compounds were evaluated against nineteen fungal strains that included Candida and Aspergillus species, Cryptococcus neoformans. The aryl aldimines 2-(benzylideneamino)phenol (3) and 4-(benzylideneamino)phenol (8) were the most active compounds against the fungi studied. Compounds 3 and 8 efficiently inhibited the metabolism of C. neoformans mature biofilm.
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