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  • Title: Chemoattractant-induced membrane hyperpolarization in Dictyostelium discoideum. A possible role for cyclic GMP.
    Author: Van Duijn B, Wang M.
    Journal: FEBS Lett; 1990 Nov 26; 275(1-2):201-4. PubMed ID: 2175716.
    Abstract:
    Membrane potentials of the cellular slime mold Dictyostelium discoideum were monitored after chemotactic stimulation by measuring the distribution of the lipophilic cation tetraphenylphosphonium. Stimulation with the chemoattractant cAMP induces a transient membrane hyperpolarization which reaches its most negative value between 1-3 min after stimulation. This hyperpolarization is consistent with the opening of potassium channels. Measurements in streamer F mutant cells reveal that cGMP likely plays a role in the regulation of the cAMP-induced hyperpolarization.
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