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  • Title: Evaluation of long-term clarithromycin treatment in adult Chinese Patients with chronic rhinosinusitis without nasal polyps.
    Author: Luo Q, Chen F, Liu W, Li Z, Xu R, Fan Y, Chen R, Xu Y, Liu Z, Xu G, Fu Q, Zuo K, Shi J, Li H, Nasal Health Group, China (NHGC).
    Journal: ORL J Otorhinolaryngol Relat Spec; 2011; 73(4):206-11. PubMed ID: 21757966.
    Abstract:
    OBJECTIVE: To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP). METHODS: Thirty-three CRSnNP patients were enrolled and subjected to CAM treatment for 12 weeks (250 mg daily). The total nasal symptom scores (TNSS), nasal resistance and inflammatory mediators including interleukin (IL)-8 and myeloperoxidase (MPO) were evaluated at weeks 0 and 12. Quality of life (QoL) was assessed in all patients by using the Sinonasal Outcome Test 20 and Short Form 36 questionnaires. RESULTS: CAM treatment significantly improved TNSS, nasal resistance and QoL, and it inhibited IL-8 and MPO production in CRSnNP patients (p < 0.05). CAM treatment was more effective for IL-8(high) CRSnNP patients than for IL-8(low) CRSnNP patients (p < 0.05). CONCLUSION: Long-term, low-dose CAM treatment is effective and safe for the treatment of CRSnNP in Chinese patients.
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