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  • Title: [Morphology of the thymus gland in children with myasthenia gravis].
    Author: Kop'eva TN, Sekamova SM.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1990; 90(9):13-7. PubMed ID: 2176031.
    Abstract:
    Thymus excised from 68 patients suffering from juvenile myasthenia was subjected to histological, histochemical and electron microscopy studies. The changes in the thymus involved hyperplastic immune response in the form of lymphoid follicles with the germinal centers and focal plasmocytic infiltration. In myasthenia, the permanent characteristic of the thymus was activation of epithelial cells and Hassal bodies. A direct relationship was discovered between the efficacy of thymectomy and intensity of hyperplasia of the glandular lobules of the thymus. The lobule number of lymphoid follicles with the germinal centers did not affect the results of the surgical treatment of patients suffering from myasthenia.
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