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  • Title: [Splenectomy in the treatment of severe forms of myasthenia gravis].
    Author: Gekht BM, Kuzin MI, Shkrob OS, Vetshev PS, Ippolitov IKh, Sanadze AG, Shagal DI, KHodzhaev ZSh.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1990; 90(9):6-9. PubMed ID: 2176044.
    Abstract:
    The authors describe the results of clinical and electromyography examinations of 20 patients with grave generalized myasthenia, carried out within the short-term (up to 2 weeks) and long-term period (up to 1 year) after splenectomy. In these patients, the preceding therapy (thymectomy, gamma-therapy of the thymic area, the treatment with prednisolone, azathioprine, plasmapheresis, etc) had not produced any beneficial effect. The efficacy of splenectomy was assessed according to the Keens classification (A-E). In the short-term period after splenectomy the C effect was recorded in 13 out of the 20 patients. Out of 9 patients examined in the long-term period, the B effect was revealed in 3 patients, the C effect persisted in 3 patients, and 3 patients manifested the return to the initial status, namely to the E effect. Therefore in the group of patients with grave generalized myasthenia, the efficacy of splenectomy amounted to 65%. In view of this fact the inclusion of the given treatment method into the multimodality treatment of myasthenic patients is regarded advisable.
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