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  • Title: Increased superoxide anion generation by alveolar macrophages stimulated with antigens associated with organic dusts.
    Author: Milanowski J, Dutkiewicz J.
    Journal: Allergol Immunopathol (Madr); 1990; 18(4):211-5. PubMed ID: 2176060.
    Abstract:
    The gaseous phase cultures of alveolar macrophages (AMs) of guinea pig were exposed to the saline extracts of the dust-borne bacteria Micropolyspora faeni (syn. Faenia rectivirgula) and Erwinia herbicola (syn. Enterobacter agglomerans) which have been added at the concentration of 1 microgram/ml to culture medium with or without complement. The effects of exposure on superoxide anion (O2-) production by AMs were assessed by the lucigenin-dependent chemiluminescence method. Both extracts caused significant (p less than 0.01) increase in O2- generation by AMs, as assessed by the 161-254% enhancement of chemiluminescence release comparing to control values. The presence of complement augmented the production of O2-, which reached a peak at 3 hrs after initial exposure. The possible significance of the generation of oxygen radicals in pathogenesis of the diseases due to exposure to agricultural dusts loaded with bacterial antigens is discussed.
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