These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Growth inhibition and morphological changes of LLC-PK1 induced by ultimobranchial calcitonins.
    Author: Inoue A, Komatsu Y, Ochiai J, Itagaki S, Nishide H, Shikano M, Hemmi H, Numao N.
    Journal: Cell Biol Int Rep; 1990 Oct; 14(10):887-96. PubMed ID: 2176131.
    Abstract:
    Ultimobranchial calcitonins (CTs), known to stimulate cAMP production, inhibited the growth of a porcine kidney cell line LLC-PK1. This inhibition was accompanied by degenerative changes including vacuole formation and cell detachment. The electron microscopic study revealed marked swelling of rough endoplasmic reticulum (RER). Other cAMP-increasing agents such as human CT, arginine, vasopressin, and forskolin showed less growth inhibitory activities and no induction of the degenerative changes. These results indicate that the growth inhibition of LLC-PK1 by ultimobranchial CTs is mainly due to cellular death caused by the swelling of RER via a signalling pathway other than the cAMP-dependent event(s).
    [Abstract] [Full Text] [Related] [New Search]