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  • Title: Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver.
    Author: Gadaleta MN, Petruzzella V, Fracasso F, Fernandez-Silva P, Cantatore P.
    Journal: FEBS Lett; 1990 Dec 17; 277(1-2):191-3. PubMed ID: 2176613.
    Abstract:
    The effect of acetyl-L-carnitine on the quantity of the messenger RNA for the subunit I of cytochrome oxidase in the liver mitochondria of hypothyroid rat was measured by Northern blot and solution hybridization. Three hours after pre-treatment of hypothyroid rat with acetyl-L-carnitine, the level of the transcript increased strongly. This effect was also obtained when acetyl-L-carnitine was administered to T3 pre-treated hypothyroid rats. These results add further evidence to the suggestion that acetyl-L-carnitine is able to stimulate mitochondrial transcription under altered metabolic conditions.
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