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  • Title: Three new cycloartane triterpenoids from Astragalus bicuspis.
    Author: Jan S, Abbaskhan A, Musharraf SG, Sattar SA, Resayes SI, Al-Othman ZA, Al-Majid AM, Choudhary MI.
    Journal: Planta Med; 2011 Nov; 77(16):1829-34. PubMed ID: 21766268.
    Abstract:
    Three new cycloartane triterpenoids have been isolated from Astragalus bicUSPIS Fisch. Their structures were elucidated as 23(R),24(S),25( R),26(S)-16 β/23,23/26,24/25-triepoxy-26-hydroxy-9,19-cyclolanosta-3,6-dione (1), 6 α,23,24,25-tetraol-16 β-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one (2), and 6 α,23,24,25-tetraol-16 β-acetoxy-23(R),24(R)-9,19-cyclolanosta-3 β- O-xyloside (3), based on their spectroscopic analysis. All cycloartane tritepenoids exhibited weak cytotoxicities against 3T3 fibroblast cells as compared to the standard drug cycloheximide. Compounds 3 and 4 were also tested for their antileishmanial potential, and a weak activity was observed against promastigotes of Leishmania major.
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