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  • Title: Three-component synthesis of neoglycopeptides using a Cu(II)-triggered aminolysis of peptide hydrazide resin and an azide-alkyne cycloaddition sequence.
    Author: Ebran JP, Dendane N, Melnyk O.
    Journal: Org Lett; 2011 Aug 19; 13(16):4336-9. PubMed ID: 21766830.
    Abstract:
    Copper(II)-induced oxidative aminolysis of hydrazides generates Cu(I), the catalyst of the azide-alkyne cycloaddition. This feature was exploited to design a novel solid phase detaching three-component reaction permitting the conversion of supported peptide hydrazides into 1,2,3-triazole linked C-terminal neoglycopeptides.
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