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  • Title: Placental mesenchymal dysplasia presenting as a twin gestation with complete molar pregnancy.
    Author: Starikov R, Goldman R, Dizon DS, Kostadinov S, Carr S.
    Journal: Obstet Gynecol; 2011 Aug; 118(2 Pt 2):445-449. PubMed ID: 21768849.
    Abstract:
    BACKGROUND: Placental mesenchymal dysplasia is a rare abnormality characterized by placentomegaly, grapelike cystic vesicles, and villous hyperplasia. The clinical and ultrasonographic presentation may mimic molar pregnancy, provoking incorrect diagnoses and unnecessary therapeutic interventions. CASE: A 36-year-old nulliparous woman presented for prenatal ultrasonography that indicated the presence of one gestational sac containing both fetus and cystic mass, concerning for partial molar pregnancy. Amniocentesis returned a 46,XX karyotype, suggesting a twin gestation with complete mole. The patient was monitored closely and, because of fetal growth restriction, was induced successfully at term and delivered a healthy newborn. Histopathologic findings of the placenta were consistent with placental mesenchymal dysplasia. CONCLUSION: Although placental mesenchymal dysplasia is often confused with molar pregnancy, it is important to consider both in a differential to avoid inappropriate treatments.
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