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  • Title: Suppression of neutrophil and lymphoproliferative responses in vitro by itraconazole but not fluconazole.
    Author: Vuddhakul V, Mai GT, McCormack JG, Seow WK, Thong YH.
    Journal: Int J Immunopharmacol; 1990; 12(6):639-45. PubMed ID: 2177039.
    Abstract:
    Itraconazole and fluconazole are triazole compounds recently licensed for the therapy of systemic fungal infections. At 10 micrograms/ml concentrations, itraconazole was found to suppress neutrophil chemotaxis, random movement, deoxyglucose uptake and hexose-monophosphate shunt activity to the same extent as ketoconazole, an older generation azole antifungal. Itraconazole was also found to suppress mitogen-induced lymphocyte transformation to the same extent as ketoconazole at concentrations as low as 1 microgram/ml. By contrast, significant inhibition of both neutrophil and lymphocyte functions was not observed with fluconazole at concentrations as high as 50 micrograms/ml. These results suggest that fluconazole may be less immunotoxic than itraconazole, and may be more suitable for use in immunocompromised patients.
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