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  • Title: Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
    Author: Cheng P, Zhu L, Guo W, Liu W, Yao J, Dong G, Zhang Y, Zhuang C, Sheng C, Miao Z, Zhang W.
    Journal: J Enzyme Inhib Med Chem; 2012 Jun; 27(3):437-42. PubMed ID: 21770860.
    Abstract:
    Structure modification of the side chain of the lead compound benzoxanthone provided a series of benzoxanthone analogues and 12 of them were first reported. The results showed that most of these compounds had moderate cytotoxicity against tumour cells with the 50% inhibition concentration in the micromolar range. Furthermore, benzoxanthone derivatives 5, 6c, 7a and 7e, showed potent topoisomerase I (Topo I) inhibitory effect and the results indicated that some compounds had potential for development as non-Camptothecin (CPT) topoisomerase I inhibitors.
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