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  • Title: Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists.
    Author: Metcalfe C, de Sauvage FJ.
    Journal: Cancer Res; 2011 Aug 01; 71(15):5057-61. PubMed ID: 21771911.
    Abstract:
    Acquired resistance to targeted therapies threatens the value of these otherwise very promising agents. The recent description of resistance to the Hedgehog pathway inhibitor vismodegib (GDC-0449) in a medulloblastoma patient who had a dramatic initial response has spurred efforts to understand potential mechanisms of drug resistance. Elucidating these mechanisms will play a significant role in informing strategies to overcome this meaningful limitation.
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