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  • Title: [Substances having antiviral activity. IX. Synthesis and antiviral activity of 1-acyl-2-halo-3-formylindole thiosemicarbazones].
    Author: Andreani A, Bonazzi D, Cavrini V, Gatti R, Giovanninetti G, Rambaldi M, Franchi L, Nanetti A, Guarda MA.
    Journal: Farmaco Sci; 1978 Oct; 33(10):754-60. PubMed ID: 217729.
    Abstract:
    Some thiosemicarbazones of 1-acyl-2-chloro-3-formylindoles were synthesized and investigated for antiviral activity against vaccinia virus, HID stock and parainfluenza virus type 3 HA-I/CR-8 stock. Evidence of antiviral activity was found only against vaccinia virus, and was particular significant with the m-substituted 1-benzoyl-2-chloro-3-formylindoles. The first results of 2-substitution of chlorine by bromine in the indole skeleton, are reported.
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