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  • Title: Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
    Author: McClellan WJ, Dai Y, Abad-Zapatero C, Albert DH, Bouska JJ, Glaser KB, Magoc TJ, Marcotte PA, Osterling DJ, Stewart KD, Davidsen SK, Michaelides MR.
    Journal: Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5620-4. PubMed ID: 21778056.
    Abstract:
    In an effort to discover Aurora kinase inhibitors, an HTS hit revealed an amide containing pyrrolopyrimidine compound. Replacement of the pyrrolopyrimidine residue with a thienopyrimidine moiety led to a series of potent and selective Aurora inhibitors.
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