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  • Title: Sustained release of 5-fluorouracil by incorporation into sodium carboxymethylcellulose sub-micron fibers.
    Author: Cai X, Luan Y, Dong Q, Shao W, Li Z, Zhao Z.
    Journal: Int J Pharm; 2011 Oct 31; 419(1-2):240-6. PubMed ID: 21782913.
    Abstract:
    This work introduces a novel route to the sodium carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug, 5-fluorouracil (5-Fu). The results show that 5-Fu is successfully incorporated into the biocompatible polymer, sodium carboxymethylcellulose (NaCMC)-based fibers with good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the 5-Fu-loaded NaCMC fibers shows a diffusion mechanism, obeying Ritger-Peppas kinetics model. The drug release behavior of the as-prepared products demonstrates their promising application in drug delivery system.
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