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  • Title: Antagonism of ethanol intoxication in rats by inhibitors of phenylethanolamine N-methyltransferase.
    Author: Mefford IN, Lister RG, Ota M, Linnoila M.
    Journal: Alcohol Clin Exp Res; 1990 Feb; 14(1):53-7. PubMed ID: 2178473.
    Abstract:
    The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated. Two selective inhibitors of phenylethanolamine N-methyltransferase (PNMT), LY134046 and LY78335, proved to be potent and long-lasting antagonists of ethanol intoxication in rats. Acute antagonism of pentobarbital-induced intoxication was observed with LY134046. The present results are compatible with a role for central epinephrine synthesis in ethanol and pentobarbital-induced sedation and intoxication in rats.
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