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  • Title: Relationship between inhibin-α gene polymorphisms and premature ovarian failure in Korean women.
    Author: Kim H, Chun S, Gu BS, Ku SY, Kim SH, Kim JG.
    Journal: Menopause; 2011 Nov; 18(11):1232-6. PubMed ID: 21785376.
    Abstract:
    OBJECTIVE: The aim of this study was to determine the relationship between inhibin-α (INHα) gene polymorphisms and the prevalence of premature ovarian failure (POF) in Korean women. METHODS: The INHα -124A/G, -16C/T, 679G/A, and 769G/A polymorphisms were analyzed in 52 women with POF and 55 normal healthy women using polymerase chain reaction-restriction enzyme fragment length polymorphism analysis. RESULTS: The 679G/A and 769G/A polymorphisms were not observed. The frequencies of the C allele of the INHα -16C/T polymorphism and the G allele of the INHα -124A/G polymorphism were significantly lower in the women with POF than in the normal control women. The frequencies of the CG haplotype allele of these INHα -16C/T and -124A/G gene polymorphisms were also significantly lower in the women with POF than in the control women. CONCLUSIONS: The INHα -16C/T and -124A/G polymorphisms are genetic factors associated with the prevalence of POF in Korean women.
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