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  • Title: Bioactive saponins from the fruits of Aesculus pavia L.
    Author: Sun ZL, Zhang M, Wu Y, Wan AH, Zhang R.
    Journal: Fitoterapia; 2011 Oct; 82(7):1106-9. PubMed ID: 21787846.
    Abstract:
    Continued chemical investigation on the fruits of Aesculus pavia L. resulted in theisolation and identification of two new oleanolic acid saponins, namely vaccaroside A (1) andvaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays.In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC₅₀ valuesin the range of 27.80-79.02 μM.
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