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  • Title: Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link.
    Author: Fulda S.
    Journal: Oncotarget; 2011 May; 2(5):418-21. PubMed ID: 21789791.
    Abstract:
    The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing over the last years. A recent study identifies a new mechanism of action for the synergism of TRAIL and Bortezomib.
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