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  • Title: Reversible nephrotoxicity of cyclosporine in rheumatoid arthritis.
    Author: Boers M, Dijkmans BA, van Rijthoven AW, Goei Thè HS, Cats A.
    Journal: J Rheumatol; 1990 Jan; 17(1):38-42. PubMed ID: 2179550.
    Abstract:
    Irreversible nephrotoxicity has limited the use of cyclosporine in rheumatoid arthritis (RA). In a randomized clinical trial we compared 26 weeks of cyclosporine (5 mg/kg) and D-penicillamine (250 mg) treatment in 92 patients with RA with a serum creatinine less than 100 mumol/l. We adjusted the starting dose according to clinical response and side effects. During cyclosporine treatment the serum creatinine increased by median 15% (p less than 0.0001 vs baseline), quickly reversible after stopping (median followup: 1.6 years). Six patients stopped cyclosporine prematurely because of nephrotoxicity. In the D-penicillamine group the values remained at baseline.
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