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  • Title: Cytotoxic and antibacterial flavonoids from dragon's blood of Dracaena cambodiana.
    Author: Luo Y, Wang H, Zhao YX, Zeng YB, Shen HY, Dai HF, Mei WL.
    Journal: Planta Med; 2011 Dec; 77(18):2053-6. PubMed ID: 21800280.
    Abstract:
    Chemical studies on the constituents from the dragon's blood of Dracaena cambodiana led to the discovery of three new flavonoid derivatives (1- 3) and six known compounds (4- 9). The structures of the three new compounds were elucidated by NMR and MS spectroscopic analyses. All compounds were evaluated for their growth inhibitory activity against human cell lines K-562, SMMC-7721, and SGC-7901, as well as antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). As a result, compounds 1, 2, 5, 7, and 9 showed cytotoxicity against K-562, SMMC-7721, and SGC-7901 cell lines. All these compounds were observed to exhibit antibacterial activities against S. aureus, and compounds 1- 4, 6, 8, and 9 were observed to exhibit antibacterial activity against MRSA.
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