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  • Title: Colorimetric detection of Cd2+ using gold nanoparticles cofunctionalized with 6-mercaptonicotinic acid and L-cysteine.
    Author: Xue Y, Zhao H, Wu Z, Li X, He Y, Yuan Z.
    Journal: Analyst; 2011 Sep 21; 136(18):3725-30. PubMed ID: 21804959.
    Abstract:
    We have developed a colorimetric assay for the highly sensitive and selective detection of Cd(2+) using gold nanoparticles (AuNPs) cofunctionalized with 6-mercaptonicotinic acid (MNA) and L-Cysteine (L-Cys) through the formation of an Au-S bond. In the presence of Cd(2+), the aggregation of functionalized AuNPs occurred by means of a metal-ligand interaction that led to visible color changes. Most importantly, cofunctionalized AuNPs had better responses for Cd(2+) than that functionalized by either MNA or L-Cys. Cd(2+) could be detected by the colorimetric response of AuNPs that could be detected by the naked eye or a UV-vis spectrophotometer. The absorbance ratio (A(620)/A(523)) was linear with the Cd(2+) concentration in the range of 2.0 × 10(-7) to 1.7 × 10(-6) M. Under optimum conditions (2.0 × 10(-5) M MNA, 2.0 × 10(-6) M L-Cys and 0.020 M NaCl at pH 10.0), the detection limit (3σ) of Cd(2+) could be as low as 1.0 × 10(-7) M. Interference experiments showed that Pb(2+) and Cu(2+) caused a slight interference for Cd(2+) determination while other metal ions caused no interference. The proposed method was successfully applied to determine the concentration of Cd(2+) in environmental samples (lake water).
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