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  • Title: Association of FAS and FAS ligand polymorphisms with the susceptibility and severity of lumbar disc degeneration in Chinese Han population.
    Author: Zhu GB, Jiang XR, Xia CL, Sun YJ, Zeng QS, Wu XM, Li XC.
    Journal: Biomarkers; 2011 Sep; 16(6):485-90. PubMed ID: 21806408.
    Abstract:
    CONTEXT: Apoptosis is involved in the mechanism of lumbar disc degeneration (LDD). OBJECTIVE: We aim to determine whether the polymorphisms of FAS and FASL are associated with the presence and severity of LDD. METHODS: A total of 348 patients with LDD and 215 healthy controls were genotyped. RESULTS: Patients with LDD showed higher frequency of-1377GA and AA, as well as-844CT and TT genotypes than normal controls. These genotypes were found to be associated with the risk of higher grades of LDD. CONCLUSION: The polymorphisms of FAS and FASL may be associated with the presence and severity of LDD.
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