These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76.
    Author: Zhong B, Lama R, Smith KM, Xu Y, Su B.
    Journal: Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5324-7. PubMed ID: 21807508.
    Abstract:
    JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still remain unclear, which significantly withdraw the further drug development of JCC76. To identify the molecular targets of JCC76, a six carbon linker and biotin conjugated JCC76 probe was designed and synthesized. The anti-proliferation activity of the probe and its analogs was evaluated.
    [Abstract] [Full Text] [Related] [New Search]