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  • Title: [Effect of curcumin on expression of Abeta42 and Abeta-degrading enzyme NEP in APPswe/PS1dE9 double transgenic mice].
    Author: Wang P, Wang H, Li R, Li Y, Ren Y, Zhu Z, Sun H, Yang J, Sun J.
    Journal: Zhongguo Zhong Yao Za Zhi; 2011 Apr; 36(8):1079-82. PubMed ID: 21809590.
    Abstract:
    OBJECTIVE: To observe the effect of curcumin on the expression of Abeta42 and its degrading enzyme NEP in APP/PS1 double transgenic mice. METHOD: 3-month old APP/PS1 dtg mice were randomly divided into model group, positive control group and curcumin large, medium and small dose group. After 3 months, Morris water maze, immunohistochemistry, Western blot were applied to detect learning and memory ability of animal. RESULT: Behavior detection, compared with the model group, treatment group showed varying degrees of difference in place navigation test and space exploration experiments (P < 0.01 or P < 0.05). The expression of Abeta42 and its degrading enzyme NEP, Abeta42-positive cells of hippocampus CA1 region significantly increased in model mice as compared with normal control group (P < 0.01). CONCLUSION: Curcumin can improve learning and memory ability of APP/PS1 double transgenic mice through increasing the expression of Abeta-degrading enzyme NEP and decreasing the expression of Abeta42.
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