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  • Title: The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.
    Author: Lee KT, Jung TW, Lee HJ, Kim SG, Shin YS, Whang WK.
    Journal: Arch Pharm Res; 2011 Jul; 34(7):1201-8. PubMed ID: 21811928.
    Abstract:
    Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.
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