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  • Title: Factors associated with recurrence and therapeutic strategies for sinonasal Rosai-Dorfman disease.
    Author: Chen HH, Zhou SH, Wang SQ, Teng XD, Fan J.
    Journal: Head Neck; 2012 Oct; 34(10):1504-13. PubMed ID: 21818818.
    Abstract:
    BACKGROUND: The purpose of this study was to explore the factors associated with the recurrence of Rosai-Dorfman disease (RDD) in the nasal cavity and paranasal sinus. METHODS: In this study, we conducted a review of the English-language literature published between 1969 and 2010 on the recurrence of and treatment strategies for sinonasal RDD. RESULTS: To our knowledge, 126 cases of RDD have been reported to date. Of the 126 patients, 32 (25.4%) had no recurrence or were alive with no evidence of disease; remission occurred in only 1 patient (0.7%); 69 patients (54.8%) had a recurrent, persistent, or progressive course; and 6 patients (4.8%) died from the disease. In patients with recurrent, persistent, and progressive disease, there was no significant tendency for lymph node involvement. CONCLUSION: Sinonasal RDD is generally described as benign. However, recurrence and fatal outcome have been reported. Our results suggest that the initial modality may affect the recurrence of RDD.
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