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  • Title: Expression of fatty acid synthase (FASN) in oral nevi and melanoma.
    Author: de Andrade BA, León JE, Carlos R, Delgado-Azañero W, Mosqueda-Taylor A, Graner E, de Almeida OP.
    Journal: Oral Dis; 2011 Nov; 17(8):808-12. PubMed ID: 21819495.
    Abstract:
    OBJECTIVE: The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. MATERIALS AND METHODS: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. RESULTS: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. CONCLUSION: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi.
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