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  • Title: Intracellular ATP levels affect secondary metabolite production in Streptomyces spp.
    Author: Meng L, Li M, Yang SH, Kim TJ, Suh JW.
    Journal: Biosci Biotechnol Biochem; 2011; 75(8):1576-81. PubMed ID: 21821936.
    Abstract:
    The addition of extracellular ATP (exATP) to four Streptomyces strains had similar effects: low exATP levels stimulated antibiotic production and high levels reduced it. Compared with antibiotic production, the concentrations of intracellular ATP (inATP) in the tested strains were opposite, which suggests a role of inATP in regulating secondary metabolite production. Under inactivation of the polyphosphate kinase gene (ppk) in Streptomyces lividans, we observed the same results: when the inATP level in the mutant strain was lower than in the parent strain, more antibiotic was produced. Combining all the results, a strong inverse relationship between [inATP] and the secondary metabolite production is suggested by this study.
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