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  • Title: [Natural course of preneoplastic bronchial lesions].
    Author: Ulmeanu R, Râjnoveanu R, Halic E, Deleanu O, Mihălţan F.
    Journal: Pneumologia; 2011; 60(2):93-8. PubMed ID: 21823361.
    Abstract:
    Advances in endoscopic technology have improved the detection of precancerous bronchial lesions associated with the occurence of proximal squamous cell lung cancer (SCC) in high-risk individuals for broncho-pulmonary neoplasm. The debates and controversies regarding the control and treatment of intraepitelial bronchial lesions is due to the fact that the regression rate of all preneoplastic bronchial lesions is 54%. But the progression to carcinoma in situ or to cancer is significantly higher for severe dysplasia, than for preneoplastic lesions showing lower-grade dysplasia, such as squamous metaplasia and mild or moderate dysplasia. The progression rate to carcinoma in situ or cancer with squamous cells varies between 19% and 46% for patients with severe dysplasia. The diagnosis and resection of pulmonary cancer in incipient stages increases spectacularly the survival rates of the resected patients, by comparison to the non-operated patients.
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