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  • Title: The effect of maternal number of births on oxidative and antioxidative systems in cord blood.
    Author: Mutlu B, Bas AY, Aksoy N, Taskin A.
    Journal: J Matern Fetal Neonatal Med; 2012 Jun; 25(6):802-5. PubMed ID: 21824039.
    Abstract:
    OBJECTIVE: The aim of this study is to evaluate the relationship between cord blood oxidative and antioxidative status and maternal parity number. METHODS: Patients are grouped according to the maternal parity number: primiparous group (n = 36), multiparous group (n = 40), and grand multiparous group (n = 26). Cord blood samples are obtained in all subjects and assessed for total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI). The serum TAC and TOS were evaluated by using an automated colorimetric measurement method. RESULTS: TAC levels are significantly higher and oxidative stress indicators are significantly lower in newborns of primiparous women compared to multiparous women p < 0.05 for all). TAC level is increased, whereas TOS and OSI levels are decreased in newborns of grand multiparous mothers compared to primiparous mothers. TAC level is significantly higher, whereas TOS and OSI levels are significantly lower in newborns of grand multiparous women compared to multiparous women (p < 0.05 for all). CONCLUSIONS: These results suggest a relation between higher maternal parity and increased oxidative stress and decreased antioxidant defense capacity. On the other hand, the compensatory mechanisms improve the antioxidant defense system in newborns of grand multiparous women and may prevent oxidative stress.
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