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  • Title: Pharmacologically directed design of leukemia therapy.
    Author: Plunkett W, Heinemann V, Estey E, Keating M.
    Journal: Haematol Blood Transfus; 1990; 33():610-3. PubMed ID: 2182451.
    Abstract:
    The ability to accumulate and retain the active metabolite of Ara-C varies widely among patients. Our studies demonstrate a significant correlation between clinical response and the pharmacokinetics of Ara-CTP in leukemia cells during therapy. Knowledge of the cellular pharmacology of Ara-CTP has been used to optimize dose rates and to design combination treatment schedules. An understanding of the cellular pharmacodynamics of other drugs is likely to be a useful parameter for planning treatment protocols.
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