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  • Title: Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives.
    Author: Devakaram R, Black DS, Andrews KT, Fisher GM, Davis RA, Kumar N.
    Journal: Bioorg Med Chem; 2011 Sep 01; 19(17):5199-206. PubMed ID: 21824783.
    Abstract:
    7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC(50) values ranging between 1.9 and 3.9 μM.
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