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  • Title: Is there a role of the local tissue RAS in the regulation of physiologic and pathophysiologic conditions in the reproductive tract?
    Author: Schwentner L, Wöckel A, Herr D, Wulff C.
    Journal: J Renin Angiotensin Aldosterone Syst; 2011 Dec; 12(4):385-93. PubMed ID: 21824991.
    Abstract:
    The renin-angiotensin system is well known as a systemic endocrine pathway that regulates blood pressure and salt-water metabolism. In addition to the systemic renin-angiotensin system there is evidence in different species for the presence of a local tissue renin-angiotensin system, which allows local production of the bioactive peptides angiotensin II and angiotensin (1-7). The local renin-angiotensin system has been found in a variety of tissues including tissue of the human reproductive tract. Thus, it was suspected that it may have important functions in the local hormonal microenvironment. Here, a systematic literature search was undertaken to review whether there is evidence for regulatory functions of the local tissue renin-angiotensin system in the human reproductive tract under physiological and pathological conditions.
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