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  • Title: Regional localization of the gene for human phosphoribosylpyrophosphate synthetase on the X chromosome.
    Author: Becker MA, Yen RC, Itkin P, Goss SJ, Seegmiller JE, Bakay B.
    Journal: Science; 1979 Mar 09; 203(4384):1016-9. PubMed ID: 218284.
    Abstract:
    Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase activity. The cells were grown under selective conditions requiring retention of the X chromosome-linked locus for human hypoxanthine-guanine phosphoribosyltransferase. The frequency and patterns of cotransference of human phosphoribosylpyrophosphate synthetase with the selected marker and with additional X-linked enzymatic markers confirm X linkage of the structural gene for human phosphoribosylpyrophosphate synthetase and support assignment of this gene to a position on the long arm of the X, between the loci for alpha-galactosidase and hypoxanthine-guanine phosphoribosyltransferase.
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