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  • Title: Two new casbane diterpenoids from the roots of Euphorbia pekinensis.
    Author: Shao FG, Bu R, Zhang C, Chen CJ, Huang J, Wang JH.
    Journal: J Asian Nat Prod Res; 2011 Sep; 13(9):805-10. PubMed ID: 21830884.
    Abstract:
    From the roots of Euphorbia pekinensis, two new casbane diterpenoids, named pekinenins A (1) and B (2), were isolated. Their structures were elucidated as 18-hydroxy-1βH,2αH-casba-3E,7E,11E-trien-5-one (1), 5α-methoxy-1βH,2αH-casba-3Z,7E,11E-trien-18-oic acid (2) by a combination of 1D and 2D NMR spectroscopy and mass spectrometry. In the cytotoxicity assay of the two new compounds against Hela, MCF-7, and C6 human cancer cell lines, compound 1 showed moderate cytotoxic activity against two human cancer cell lines, Hela and C6, with IC(50) values of 42.97 and 50.00 μM, respectively.
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