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  • Title: Identification of the metabolites of baicalein in human plasma.
    Author: Guo XY, Yang L, Chen Y, Wang QF, Sun QS, Che YX, Che QM.
    Journal: J Asian Nat Prod Res; 2011 Sep; 13(9):861-8. PubMed ID: 21830892.
    Abstract:
    The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.
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