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  • Title: Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis.
    Author: Rioboo M, García V, Serrano J, O'Connor A, Herrera D, Sanz M.
    Journal: Int J Dent Hyg; 2012 May; 10(2):98-106. PubMed ID: 21831254.
    Abstract:
    OBJECTIVES: the aim of this study was to evaluate the effects of the use of a mouth rinse and dentifrice with cetylpyridinium chloride (CPC) in patients with gingivitis. METHODS: the study was designed as a 1-month, double-blind, parallel, randomized clinical trial comparing a negative control regimen (minus active ingredients dentifrice and mouth rinse) with the test products (dentifrice and mouth rinse with 0.05% CPC) in terms of plaque and gingival indexes (PI, GI), patient-based and microbiological outcome variables. The comparisons in relation to the main outcome variables (PI and GI) were made by means of the t-test, either unpaired or paired for the intergroup and intragroup comparisons, respectively. RESULTS: no differences were detected at baseline. Both groups showed statistically significant decreases in GI (0.17-0.19), without intergroup differences. The PI demonstrated a significant decrease of -0.12 in the test group and minor changes in the negative control group (increase of +0.01). Differences between groups showed a tendency towards statistical significance. A limited impact was observed for microbiological variables in both groups. CONCLUSION: the results of this study show limited benefits of the evaluated formulations as adjuncts to unsupervised oral hygiene in reducing plaque accumulation, and no effect on gingivitis.
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