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  • Title: Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth.
    Author: Shin SJ, Lee W, Lee JI, Baek SH, Kum KY, Shon WJ, Bae KS.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2011 Oct; 112(4):548-54. PubMed ID: 21831678.
    Abstract:
    OBJECTIVE: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in gingival crevicular fluid (GCF) during root canal treatment (RCT) of nonvital teeth. STUDY DESIGN: Patients scheduled for nonsurgical RCT were prospectively selected; all patients provided informed consent. GCF samples were collected from teeth scheduled for RCT and their contralateral teeth across 3 different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis. RESULTS: Patients' subjective pain levels were significantly related to both MMP-8 and SP levels. MMP-8 and SP levels in GCF were decreased during RCT, and they showed a positive correlation with each other (P < .05). CONCLUSIONS: This study demonstrated that periradicular inflammation of endodontic origin can elevate SP and MMP-8 levels in GCF.
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