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  • Title: Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage.
    Author: Alafaci C, Jansen I, Arbab MA, Shiokawa Y, Svendgaard NA, Edvinsson L.
    Journal: Acta Physiol Scand; 1990 Mar; 138(3):317-9. PubMed ID: 2183539.
    Abstract:
    The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm.
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